Article
The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1.
Molecular and cellular biology - 1 Jul 2010
Pfirrmann Thorsten, Heessen Stijn, Omnus Deike J, Andréasson Claes, Ljungdahl Per O
Abstract excerpt
Extracellular amino acids induce the yeast SPS sensor to endoproteolytically cleave transcription factors Stp1 and Stp2 in a process termed receptor-activated proteolysis (RAP). Ssy5, the activating endoprotease, is synthesized with a large N-terminal prodomain and a C-terminal chymotrypsin-like catalytic (Cat) domain. During biogenesis, Ssy5 cleaves itself and the prodomain and Cat domain remain associated,...
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