Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypes on demand via switchable target protein degradation in multicellular organisms.

Nature communications - 22 Jul 2016

Faden Frederik, Ramezani Thomas, Mielke Stefan, Almudi Isabel, Nairz Knud, Froehlich Marceli S, Höckendorff Jörg, Brandt Wolfgang, Hoehenwarter Wolfgang, Dohmen R Jürgen, Schnittger Arp, Dissmeyer Nico

Abstract excerpt

Phenotypes on-demand generated by controlling activation and accumulation of proteins of interest are invaluable tools to analyse and engineer biological processes. While temperature-sensitive alleles are frequently used as conditional mutants in microorganisms, they are usually difficult to identify in multicellular species. Here we present a versatile and transferable, genetically stable system based on a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arabidopsis
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila

Share to Nicotiana

Share to Proteolysis

Share to Saccharomyces cerevisiae

Share to Species Specificity

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 27447739
DOI: 10.1038/ncomms12202
PMCID: PMC4961840

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypes on demand via switchable target protein degradation in multicellular organisms.PMID 27447739Read ↗

Generic tools for conditionally altering protein abundance and phenotypes on demand.Semantic proximity Read ↗

Inducible degron and its application to creating conditional mutants.Semantic proximity Read ↗

Targeted protein depletion in Saccharomyces cerevisiae by activation of a bidirectional degron.Semantic proximity Read ↗

Photo-sensitive degron variants for tuning protein stability by light.Semantic proximity Read ↗

Engineering the auxin-inducible degron system for tunable <i>in vivo</i> control of organismal physiologySemantic proximity Read ↗

A temperature-inducible protein module for control of mammalian cell fateSemantic proximity Read ↗

Efficient protein depletion by genetically controlled deprotection of a dormant N-degron.Semantic proximity Read ↗

Comparative analysis and directed protein evolution yield an improved degron technology with minimal basal degradation, rapid inducible depletion, and faster recovery of target proteins.Semantic proximity Read ↗

Heat-inducible degron and the making of conditional mutants.Semantic proximity Read ↗

Genetic Code Expansion Tools to Study Lysine AcylationSemantic proximity Read ↗

The prodomain of Ssy5 protease controls receptor-activated proteolysis of transcription factor Stp1.Semantic proximity Read ↗

One-step generation of auxin-inducible degron cells with high-efficiency homozygous taggingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.