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Article

Structural bases of signal generation and transduction by the SPS amino acid sensor of Saccharomyces cerevisiae.

G3 (Bethesda, Md.) - 4 Mar 2026

Scharff-Poulsen Peter, Kielland-Brandt Morten C

Abstract excerpt

Ssy1 in Saccharomyces cerevisiae is an amino acid receptor evolved from amino acid transporters. It is situated in the plasma membrane in the SPS complex, together with the WD40-repeat protein Ptr3 and the endoprotease Ssy5. Binding of extracellular amino acids to Ssy1 triggers liberation of the catalytic domain of Ssy5, which removes an inhibitory domain from the transcription factor Stp1, freeing it to activate...

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Identifiers

PMID: 41437840
DOI: 10.1093/g3journal/jkaf312
PMCID: PMC12958826

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