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Article

Ssy5 is a signaling serine protease that exhibits atypical biogenesis and marked S1 specificity.

The Journal of biological chemistry - 1 Jun 2018

Martins António, Pfirrmann Thorsten, Heessen Stijn, Sundqvist Gustav, Bulone Vincent, Andréasson Claes, Ljungdahl Per O

Abstract excerpt

Ssy5 is a signaling endoprotease that plays a key role in regulating central metabolism, cellular aging, and morphological transitions important for growth and survival of yeast (Saccharomyces cerevisiae) cells. In response to extracellular amino acids, Ssy5 proteolytically activates the transcription factors Stp1 and Stp2, leading to enhanced Ssy1-Ptr3-Ssy5 (SPS) sensor-regulated gene expression. Ssy5 comprises...

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Identifiers

PMID: 29661936
DOI: 10.1074/jbc.RA118.002457
PMCID: PMC5986222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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