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Article

Ssy5 is a signaling serine protease that exhibits atypical biogenesis and marked S1 specificity.

The Journal of biological chemistry - 1 Jun 2018

Martins António, Pfirrmann Thorsten, Heessen Stijn, Sundqvist Gustav, Bulone Vincent, Andréasson Claes, Ljungdahl Per O

Abstract excerpt

Ssy5 is a signaling endoprotease that plays a key role in regulating central metabolism, cellular aging, and morphological transitions important for growth and survival of yeast (Saccharomyces cerevisiae) cells. In response to extracellular amino acids, Ssy5 proteolytically activates the transcription factors Stp1 and Stp2, leading to enhanced Ssy1-Ptr3-Ssy5 (SPS) sensor-regulated gene expression. Ssy5 comprises...

Topics

Amino Acid Sequence
DNA-Binding Proteins
Mutagenesis, Site-Directed
Mutation
Nuclear Proteins
Phosphorylation
RNA-Binding Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sequence Homology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Serine Proteases

Substrate Specificity

Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29661936
DOI: 10.1074/jbc.RA118.002457
PMCID: PMC5986222

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