Article
Efficient protein depletion by genetically controlled deprotection of a dormant N-degron.
Molecular systems biology - 1 Jan 2009
Taxis Christof, Stier Gunter, Spadaccini Roberta, Knop Michael
Abstract excerpt
Methods that allow for the manipulation of genes or their products have been highly fruitful for biomedical research. Here, we describe a method that allows the control of protein abundance by a genetically encoded regulatory system. We developed a dormant N-degron that can be attached to the N-terminus of a protein of interest. Upon expression of a site-specific protease, the dormant N-degron becomes...
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