Article

Toxin-based screening of C-terminal tags in <i>Escherichia coli</i> reveals the exceptional potency of ssrA-like degrons

2024-01-31

Abstract excerpt

<h4>ABSTRACT</h4> All bacteria possess ATP-dependent proteases that destroy cytosolic proteins. These enzymes help cells mitigate proteotoxic stress, adapt to changing nutrient availability, regulate virulence phenotypes, and transition to pathogenic lifestyles. Moreover, ATP-dependent proteases have emerged as promising antibacterial and antivirulence targets in a variety of pathogens. The physiological roles of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6a239ea-3af9-5df9-bf04-132cee54a091
DOI: 10.1101/2024.01.29.576913

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Toxin-based screening of C-terminal tags in <i>Escherichia coli</i> reveals the exceptional potency of ssrA-like degronsDOI 10.1101/2024.01.29.576913Read

Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteriaSemantic proximity Read

A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescensSemantic proximity Read

Development of a New N-Terminomic Method to Study the Pathodegradome of the <i>Staphylococcus aureus</i> V8 Protease in Human NeutrophilsSemantic proximity Read

Extracellular proteases are key mediators of <scp> <i>S</i> </scp> <i>taphylococcus aureus</i> virulence via the global modulation of virulence‐determinant stabilitySemantic proximity Read

Systematic Discovery of Antibacterial and Antifungal Bacterial ToxinsSemantic proximity Read

Function of site-2 proteases in bacteria and bacterial pathogens.Semantic proximity Read

Type I Signal Peptidase and Protein Secretion in Staphylococcus aureusSemantic proximity Read

Selection of Streptomyces griseus protease B mutants with desired alterations in primary specificity using a library screening strategy.Semantic proximity Read

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors of <i>Staphylococcus aureus</i>Semantic proximity Read

Decoding toxicity: deducing the sequence requirements of IbsC, a type I toxin in Escherichia coli.Semantic proximity Read

<i>In silico</i> discovery of the myxosortases that process MYXO-CTERM and three novel prokaryotic C-terminal protein-sorting signals that share invariant Cys residuesSemantic proximity Read

Bacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulence.Semantic proximity Read