Article
Activation of the SPS amino acid-sensing pathway in Saccharomyces cerevisiae correlates with the phosphorylation state of a sensor component, Ptr3.
Molecular and cellular biology - 1 Jan 2008
Liu Zhengchang, Thornton Janet, Spírek Mário, Butow Ronald A
Abstract excerpt
Cells of the budding yeast Saccharomyces cerevisiae sense extracellular amino acids and activate expression of amino acid permeases through the SPS-sensing pathway, which consists of Ssy1, an amino acid sensor on the plasma membrane, and two downstream factors, Ptr3 and Ssy5. Upon activation of SPS signaling, two transcription factors, Stp1 and Stp2, undergo Ssy5-dependent proteolytic processing that enables...
Topics
- Amino Acids
- Carrier Proteins
- Casein Kinase I
- Membrane Proteins
- Mutation
- Phosphoproteins
- Phosphorylation
- Protein Binding
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins