Article
Transcription factor mutations in myelodysplastic/myeloproliferative neoplasms.
Haematologica - 1 Sept 2010
Ernst Thomas, Chase Andrew, Zoi Katerina, Waghorn Katherine, Hidalgo-Curtis Claire, Score Joannah, Jones Amy, Grand Francis, Reiter Andreas, Hochhaus Andreas, Cross Nicholas C P
Abstract excerpt
BACKGROUND: Aberrant activation of tyrosine kinases, caused by either mutation or gene fusion, is of major importance for the development of many hematologic malignancies, particularly myeloproliferative neoplasms. We hypothesized that hitherto unrecognized, cytogenetically cryptic tyrosine kinase fusions may be common in non-classical or atypical myeloproliferative neoplasms and related...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.