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Chromoanagenesis in Myelodysplastic Syndromes Is Associated With Highly Complex Karyotype, TP53 Disruption, and Dismal Prognosis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2026

Wei Qing, Medeiros L Jeffrey, Loghavi Sanam, Leighton Jake S, Hu Shimin, Toruner Gokce A, Ok Chi Young, Kanagal-Shamanna Rashmi, Xu Jie, Garcia-Manero Guillermo, Tang Guilin

Abstract excerpt

Chromoanagenesis (CAG) is a catastrophic genomic event characterized by extensive chromosomal rearrangements and copy number alterations. It has been associated with complex karyotypes and poor outcomes in acute myeloid leukemia. However, its prevalence and associated clinicopathologic and cytogenomic features in myelodysplastic syndromes (MDSs) remain incompletely defined. In this study, we performed optical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42320760
DOI: 10.1016/j.modpat.2026.101031

Genes

TP53
HMGA1
KMT2A
PIM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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