Article
Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes.
BMC cancer - 16 Oct 2008
Gelsi-Boyer Véronique, Trouplin Virginie, Adélaïde José, Aceto Nicola, Remy Virginie, Pinson Stephane, Houdayer Claude, Arnoulet Christine, Sainty Danielle, Bentires-Alj Mohamed, Olschwang Sylviane, Vey Norbert, Mozziconacci Marie-Joëlle, Birnbaum Daniel, Chaffanet Max
Abstract excerpt
BACKGROUND: Chronic myelomonocytic leukemia (CMML) is a hematological disease close to, but separate from both myeloproliferative disorders (MPD) and myelodysplastic syndromes and may show either myeloproliferative (MP-CMML) or myelodysplastic (MD-CMML) features. Not much is known about the molecular biology of this disease. METHODS: We studied a series of 30 CMML samples (13 MP- and 11 MD-CMMLs, and 6 acutely...
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