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Article

Altered NFE2 activity predisposes to leukemic transformation and myelosarcoma with AML-specific aberrations

12 Feb 2019

Abstract excerpt

Abstract In acute myeloid leukemia (AML), acquired genetic aberrations carry prognostic implications and guide therapeutic decisions. Clinical algorithms have been improved by the incorporation of novel aberrations. Here, we report the presence and functional characterization of mutations in the transcription factor NFE2 in patients with AML and in a patient with myelosarcoma. We previously described NFE2...

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Identifiers

PMID: 30755419
DOI: 10.1182/blood-2018-09-875047

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