Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions.

doi:10.1182/blood-2010-09-308726

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Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions.

Blood - 14 Apr 2011

Quentin Samuel, Cuccuini Wendy, Ceccaldi Raphael, Nibourel Olivier, Pondarre Corinne, Pagès Marie-Pierre, Vasquez Nadia, Dubois d'Enghien Catherine, Larghero Jérôme, Peffault de Latour Régis, Rocha Vanderson, Dalle Jean-Hugues, Schneider Pascale, Michallet Mauricette, Michel Gérard, Baruchel André, Sigaux François, Gluckman Eliane, Leblanc Thierry, Stoppa-Lyonnet Dominique, Preudhomme Claude, Socié Gérard, Soulier Jean

Abstract excerpt

Fanconi anemia (FA) is a genetic condition associated with bone marrow (BM) failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). We studied 57 FA patients with hypoplastic or aplastic anemia (n = 20), MDS (n = 18), AML (n = 11), or no BM abnormality (n = 8). BM samples were analyzed by karyotype, high-density DNA arrays with respect to paired fibroblasts, and by selected oncogene sequencing. A...

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Identifiers

PMID: 21325596
DOI: 10.1182/blood-2010-09-308726

Genes

RUNX1
CBL
ERG
FLT3
NPM1
NRAS
PRDM16
TET2

Provenance

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