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Article

Absence of hotspot mutations in exons 9 and 20 of the PIK3CA gene in human oral squamous cell carcinoma in the Greek population.

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics - 1 May 2010

Kostakis George C, Papadogeorgakis Nikos, Koumaki Vasiliki, Kamakari Smaragda, Koumaki Dimitra, Alexandridis Constantinos

Abstract excerpt

OBJECTIVE: Phosphatidylinositol-3 kinases (PI3K) are a group of heterodimeric lipid kinases that regulate many cellular processes. Recent studies have reported high frequencies of somatic hotspot mutations in the phosphatidylinositol-3 kinase catalytic alpha (PIK3CA) gene, which encodes for one of these kinases, in several human solid tumors, including oral squamous cell carcinoma (OSCC). The aim of this study...

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PMID: 20416519
DOI: 10.1016/j.tripleo.2010.01.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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