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Article

Novel mutations of the HRAS gene and absence of hotspot mutations of the BRAF genes in oral squamous cell carcinoma in a Greek population.

Oncology reports - 1 May 2012

Koumaki Dimitra, Kostakis George, Koumaki Vasiliki, Papadogeorgakis Nikolaos, Makris Michael, Katoulis Alexandros, Kamakari Smaragda, Koutsodontis George, Perisanidis Christos, Lambadiari Vaia, Chrysomali Evanthia, Stavrianeas Nikolaos, Alexandridis Constantinos, Rigopoulos Dimitrios

Abstract excerpt

Oral squamous cell carcinoma (OSCC) is the sixth most common cancer in the world. The phosphatidylinositol 3 kinase (PI3K) signalling pathway has been reported to play an important role in OSCC. Since we have previously detected absence of hotspot PIK3CA gene mutations in the Greek population, we hypothesized that BRAF or HRAS may be activated as upstream effectors...

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Identifiers

PMID: 22294102
DOI: 10.3892/or.2012.1653

Genes

HRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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