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Article

Analysis of PIK3CA and Akt/protein kinase B in head and neck squamous cell carcinoma.

Oncology reports - 1 Jul 2007

Fenic Irina, Steger Klaus, Gruber Christin, Arens Christoph, Woenckhaus Joachim

Abstract excerpt

PIK3CA, which encodes the catalytic subunit, p110-alpha, of phosphatidylinositol 3-kinase (PI3K), is implicated in the development and progression of numerous neoplasias including head and neck squamous cell carcinoma (HNSCC). In the present study, we investigated the occurrence of PIK3CA hot-spot mutations in exons 9 and 20, the genomic gain and amplification of PIK3CA, the expression of PIK3CA mRNA and the p110...

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Share to Carcinoma, Squamous Cell
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17549376

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