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Article

A novel PIK3CA hotspot mutation in Isfahanian breast cancer patients.

Cancer investigation - 1 May 2011

Gharbi Sedigheh, Faghihi Mehri, Tavassoli Manoochehr

Abstract excerpt

Somatic mutations of phosphatidylinositol 3-kinase (PI3K) catalytic subunit (PIK3CA) play an important role in tumorigenesis. Using PCR-SSCP, followed by sequencing, we examined the PIK3CA gene over the previously identified mutational hotspots in a panel of 50 breast cancer and 5 normal breast tissue, as well as 50 normal blood samples isolated from a population of Iranian patients. In the present study, the...

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Identifiers

PMID: 21345071
DOI: 10.3109/07357907.2010.550593

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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