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Article

Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2010

Mangravite Lara M, Medina Marisa Wong, Cui Jinrui, Pressman Sheila, Smith Joshua D, Rieder Mark J, Guo Xiuqing, Nickerson Deborah A, Rotter Jerome I, Krauss Ronald M

Abstract excerpt

OBJECTIVE: Although statins are efficacious for lowering low-density lipoprotein cholesterol, there is wide interindividual variation in response. We tested the extent to which combined effects of common alleles of LDLR and HMGCR can contribute to this variability. METHODS AND RESULTS: Haplotypes in the LDLR 3'-untranslated region (3-UTR) were tested for association with lipid-lowering response to simvastatin...

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Source

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Identifiers

PMID: 20413733
DOI: 10.1161/ATVBAHA.110.203273
PMCID: PMC2909117

Genes

LDLR
HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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