Article
Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment.
Circulation - 25 Mar 2008
Krauss Ronald M, Mangravite Lara M, Smith Joshua D, Medina Marisa W, Wang Dai, Guo Xiuqing, Rieder Mark J, Simon Joel A, Hulley Steven B, Waters David, Saad Mohammed, Williams Paul T, Taylor Kent D, Yang Huiying, Nickerson Deborah A, Rotter Jerome I
Abstract excerpt
BACKGROUND: Use of 3-hydroxyl-3-methylglutaryl-3 coenzyme A reductase (HMGCR) inhibitors, or statins, reduces cardiovascular disease risk by lowering plasma low-density lipoprotein cholesterol (LDL-C) concentrations. However, LDL-C response is variable and influenced by many factors, including ra...
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