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Article

Pharmacogenomic analysis of low-density lipoprotein receptor 3' untranslated region genetic variants influencing rosuvastatin efficacy in Chinese dyslipidemia patients.

Pharmacogenetics and genomics - 1 Dec 2025

Wang Keke, Zhu Yihua, Tian Yan, Qin Jingli, Wang Zhuo, Zhang Guoqiang, Wang Luyan, Zhang Yanwei, Yuan Hong, Sun Ningling, Hu Songnian, Ma Yayu

Abstract excerpt

OBJECTIVES: Dyslipidemia is a crucial risk factor for atherosclerotic cardiovascular disease. Although rosuvastatin is widely used, treatment response varies significantly due to genetic variation. This study investigated the pharmacogenomic impact of low-density lipoprotein receptor (LDLR) 3' untranslated region (UTR) variants on rosuvastatin efficacy in a Chinese Han adult cohort with dyslipidemia. METHODS: A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40910988
DOI: 10.1097/FPC.0000000000000575
PMCID: PMC12456195

Genes

LDLR
TG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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