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Article

Balance between SIRT1 and DBC1 expression is lost in breast cancer

24 Mar 2010

Abstract excerpt

SIRT1 (silent mating-type information regulation 2 homologue 1)-mediated cellular resistance to various stresses is negatively regulated by deleted in breast cancer 1 (DBC1), which was originally reported to be deleted in breast cancer. However, the suggested functions of SIRT1 as a potential tumor promoter and of DBC1 as a potential tumor suppressor have been challenged by observations of their respective down-...

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PMID: 20412117
DOI: 10.1111/j.1349-7006.2010.01573.x

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