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Article

A c-Myc–SIRT1 feedback loop regulates cell growth and transformation

13 Apr 2009

Abstract excerpt

The protein deacetylase SIRT1 has been implicated in a variety of cellular functions, including development, cellular stress responses, and metabolism. Increasing evidence suggests that similar to its counterpart, Sir2, in yeast, Caenorhabditis elegans, and Drosophila melanogaster, SIRT1 may function to regulate life span in mammals. However, SIRT1's role in cancer is unclear. During our investigation of SIRT1,...

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Identifiers

PMID: 19364925
DOI: 10.1083/jcb.200809167

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