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Article

Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.

The Journal of biological chemistry - 6 Jul 2012

Nin Veronica, Escande Carlos, Chini Claudia C, Giri Shailendra, Camacho-Pereira Juliana, Matalonga Jonathan, Lou Zhenkun, Chini Eduardo N

Abstract excerpt

The NAD(+)-dependent deacetylase SIRT1 is a key regulator of several aspects of metabolism and aging. SIRT1 activation is beneficial for several human diseases, including metabolic syndrome, diabetes, obesity, liver steatosis, and Alzheimer disease. We have recently shown that the protein deleted in breast cancer 1 (DBC1) is a key regulator of SIRT1 activity in vivo. Furthermore, SIRT1 and DBC1 form a dynamic...

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Identifiers

PMID: 22553202
DOI: 10.1074/jbc.M112.365874
PMCID: PMC3390625

Genes

SIRT1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.PMID 22553202Read ↗

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