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Article

SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer

1 Jan 2013

Abstract excerpt

BACKGROUND: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by inhibiting several oncogenes such as β-catenin and survivin. Deleted in breast cancer 1 (DBC1) is known as a negative regulator of SIRT1. METHODS: Immunohistochemical expressions of SIRT1, DBC1, β-catenin, surviving, and...

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PMID: 24009628
DOI: 10.4132/koreanjpathol.2013.47.4.332

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