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Article

Janus‐faced role of SIRT1 in tumorigenesis

1 Oct 2012

Abstract excerpt

Silent mating type information regulation 1 (Sirtuin 1; SIRT1) has been reported to regulate various physiological events, such as aging and metabolism, via deacetylation of histone and nonhistone proteins. Notably, cumulative evidence supports the notion that SIRT1 has a Janus-faced role in tumorigenesis. SIRT1 contributes to anti-inflammation, genomic stability, and cancer cell death, and hence it has...

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PMID: 23050959
DOI: 10.1111/j.1749-6632.2012.06762.x

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