Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 protein

15 May 2013

Abstract excerpt

Silent mating-type information regulation 2 homologue 1 (SIRT1), a member of the class III histone deacetylase (HDAC) family, is the mammalian ortholog of yeast Sir2. It has been reported to play a key role in a variety of physiological processes such as genomic stability, metabolism, neurogenesis and cell survival. The deacetylase function of SIRT1 has been suggested to play a role in prolonging the life of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genomics, phytochemicals, and oxidative stress
Share to Plant Gene Expression Analysis
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23673452
DOI: 10.3892/or.2013.2470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SIRT1 suppresses breast cancer growth through downregulation of the Bcl-2 proteinPMID 23673452Read ↗

Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast CancerSemantic proximity Read ↗

Balance between SIRT1 and DBC1 expression is lost in breast cancerSemantic proximity Read ↗

Inhibition of sirtuin 1 deacetylase by miR-211-5p provides a mechanism for the induction of cell death in breast cancer cellsSemantic proximity Read ↗

Serum SIRT1 Levels and Gene Polymorphisms in Breast Cancer: A Biomarker and Genetic Association Study.Semantic proximity Read ↗

The Clinical Significance of SIRT2 in Malignancies: A Tumor Suppressor or an Oncogene?Semantic proximity Read ↗

SIRT1-dependent epigenetic regulation of H3 and H4 histone acetylation in human breast cancerSemantic proximity Read ↗

SIRT1 Expression Is Associated with Good Prognosis in Colorectal CancerSemantic proximity Read ↗

SIRT1: a potential tumour biomarker and therapeutic targetSemantic proximity Read ↗

Association between SIRT1 Gene Polymorphisms and Breast Cancer in Egyptians.Semantic proximity Read ↗

The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune responseSemantic proximity Read ↗

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.Semantic proximity Read ↗

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.