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Breaking down the Contradictory Roles of Histone Deacetylase SIRT1 in Human Breast Cancer

30 Oct 2018

Abstract excerpt

Breast cancer (BC) is the most common type of cancer in women worldwide; it is a multifactorial genetic disease. Acetylation and deacetylation are major post-translational protein modifications that regulate gene expression and the activity of a myriad of oncoproteins. Aberrant deacetylase activity can promote or suppress tumorigenesis and cancer metastasis in different types of human cancers, including breast...

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Autophagy in Disease and Therapy
Histone Deacetylase Inhibitors Research
Sirtuins and Resveratrol in Medicine

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30380732
DOI: 10.3390/cancers10110409

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