Article
A novel crosstalk between BRCA1 and sirtuin 1 in ovarian cancer.
Scientific reports - 17 Oct 2014
Li Da, Bi Fang-Fang, Chen Na-Na, Cao Ji-Min, Sun Wu-Ping, Zhou Yi-Ming, Li Chun-Yan, Yang Qing
Abstract excerpt
BRCA mutations are the main known hereditary factors for ovarian cancer. Notably, emerging evidence has led to considerable interest in the role of sirtuin 1 (SIRT1) in ovarian cancer development. However, dynamic crosstalk between BRCA1 and SIRT1 is poorly understood. Here, we showed that: (i) BRCA1 inactivation events (mutation, promoter methylation, or knockdown) were accompanied by decreased SIRT1 levels and...
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