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Article

A mutation in the gene encoding the vaccinia virus 37,000-M(r) protein confers resistance to an inhibitor of virus envelopment and release.

Journal of virology - 1 Jul 1991

Schmutz C, Payne L G, Gubser J, Wittek R

Abstract excerpt

Plaque formation in vaccinia virus is inhibited by the compound N1-isonicotinoyl-N2-3-methyl-4-chlorobenzoylhydrazine (IMCBH). We have isolated a mutant virus that forms wild-type plaques in the presence of the drug. Comparison of wild-type and mutant virus showed that both viruses produced similar amounts of infectious intracellular naked virus in the presence of the drug. In contrast to the mutant, no...

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Identifiers

PMID: 2041074
DOI: 10.1128/JVI.65.7.3435-3442.1991
PMCID: PMC241324

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