A mutation in the gene encoding the vaccinia virus 37,000-M(r) protein confers resistance to an inhibitor of virus envelopment and release.

doi:10.1128/JVI.65.7.3435-3442.1991

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Article

A mutation in the gene encoding the vaccinia virus 37,000-M(r) protein confers resistance to an inhibitor of virus envelopment and release.

Journal of virology - 1 Jul 1991

Schmutz C, Payne L G, Gubser J, Wittek R

Abstract excerpt

Plaque formation in vaccinia virus is inhibited by the compound N1-isonicotinoyl-N2-3-methyl-4-chlorobenzoylhydrazine (IMCBH). We have isolated a mutant virus that forms wild-type plaques in the presence of the drug. Comparison of wild-type and mutant virus showed that both viruses produced simil...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cells, Cultured
Drug Resistance, Microbial
Genes, Viral
In Vitro Techniques
Isoniazid
Molecular Sequence Data
Molecular Weight
Mutation
Rabbits
Restriction Mapping
Vaccinia virus
Viral Envelope Proteins
Viral Plaque Assay
Viral Structural Proteins
Virus Replication

Source

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Identifiers

PMID: 2041074
DOI: 10.1128/JVI.65.7.3435-3442.1991
PMCID: PMC241324

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2041074-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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