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Article

Mapping and phenotypic analysis of spontaneous isatin-beta-thiosemicarbazone resistant mutants of vaccinia virus.

Virology - 5 Jul 2007

Cresawn Steven G, Prins Cindy, Latner Donald R, Condit Richard C

Abstract excerpt

Treatment of wild type vaccinia virus infected cells with the anti-poxviral drug isatin-beta-thiosemicarbazone (IBT) induces the viral postreplicative transcription apparatus to synthesize longer-than-normal mRNAs through an unknown mechanism. Previous studies have shown that virus mutants resistant to or dependent on IBT affect genes involved in control of viral postreplicative transcription elongation. This...

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Identifiers

PMID: 17336362
DOI: 10.1016/j.virol.2007.02.005
PMCID: PMC1950264

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Source receipt: pubmed, retrieved 7 Sept 2026.

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