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Article

Vaccinia virus mutants with alanine substitutions in the conserved G5R gene fail to initiate morphogenesis at the nonpermissive temperature.

Journal of virology - 1 Oct 2004

da Fonseca Flavio G, Weisberg Andrea S, Caeiro Maria F, Moss Bernard

Abstract excerpt

The initial characterization of the product of the vaccinia virus G5R gene, which is conserved in all poxviruses sequenced to date, is described. The G5 protein was detected in the core fraction of purified virions, and transcription and translation of the G5R open reading frame occurred early in infection, independently of DNA replication. Attempts to delete the G5R gene and isolate a replication-competent virus...

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Identifiers

PMID: 15367589
DOI: 10.1128/JVI.78.19.10238-10248.2004
PMCID: PMC516429

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Source receipt: pubmed, retrieved 7 Sept 2026.

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