Article
Long-term control of HIV-1 in hemophiliacs carrying slow-progressing allele HLA-B*5101.
Journal of virology - 1 Jul 2010
Kawashima Yuka, Kuse Nozomi, Gatanaga Hiroyuki, Naruto Takuya, Fujiwara Mamoru, Dohki Sachi, Akahoshi Tomohiro, Maenaka Katsumi, Goulder Philip, Oka Shinichi, Takiguchi Masafumi
Abstract excerpt
HLA-B*51 alleles are reported to be associated with slow disease progression to AIDS, but the mechanism underlying this association is still unclear. In the present study, we analyzed the effect of HLA-B*5101 on clinical outcome for Japanese hemophiliacs who had been infected with HIV-1 before 1985 and had been recruited in 1998 for this study. HLA-B*5101(+) hemophiliacs exhibited significantly slow progression....
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