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Article

Selection of TI8-8V mutant associated with long-term control of HIV-1 by cross-reactive HLA-B*51:01-restricted cytotoxic T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2014

Kuse Nozomi, Akahoshi Tomohiro, Gatanaga Hiroyuki, Ueno Takamasa, Oka Shinichi, Takiguchi Masafumi

Abstract excerpt

Elite controllers of HIV-1-infected HLA-B*51:01(+) hemophiliacs, who remain disease free and have a very low plasma viral load for >30 y, had the 8V mutation at an immunodominant Pol283-8 (TI8) epitope, whereas the 8T mutant was predominantly selected in other HIV-1-infected HLA-B*51:01(+) hemophiliacs, suggesting an important role of the 8V mutant selection in long-term control of HIV-1. However, the mechanism...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epitopes, T-Lymphocyte

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Source

Identifiers

PMID: 25305317
DOI: 10.4049/jimmunol.1401419

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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