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Article

TRIM5α Disrupts the Structure of Assembled HIV-1 Capsid Complexes <i>In Vitro</i>

22 Apr 2010

Abstract excerpt

The host restriction factor TRIM5alpha provides intrinsic defense against retroviral infections in mammalian cells. TRIM5alpha blocks infection by targeting the viral capsid after entry but prior to completion of reverse transcription, but whether this interaction directly alters the structure of the viral capsid is unknown. A previous study reported that rhesus macaque TRIM5alpha protein stably associates with...

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PMID: 20410272
DOI: 10.1128/jvi.00210-10

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Related research

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Research trail→

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TRIM5α Disrupts the Structure of Assembled HIV-1 Capsid Complexes <i>In Vitro</i>PMID 20410272Read ↗

CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5α.Semantic proximity Read ↗

Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted InfectionSemantic proximity Read ↗

Restriction of HIV-1 by rhesus TRIM5α is governed by alpha helices in the Linker2 region.Semantic proximity Read ↗

Proteasomal Degradation of TRIM5α during Retrovirus RestrictionSemantic proximity Read ↗

The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys.Semantic proximity Read ↗

TRIM5α selectively binds a restriction-sensitive retroviral capsidSemantic proximity Read ↗

Proteasome Inhibition Reveals that a Functional Preintegration Complex Intermediate Can Be Generated during Restriction by Diverse TRIM5 ProteinsSemantic proximity Read ↗

Retroviral restriction factor TRIM5alpha is a trimer.Semantic proximity Read ↗

The Three-Fold Axis of the HIV-1 Capsid Lattice Is the Species-Specific Binding Interface for TRIM5α.Semantic proximity Read ↗

RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating.Semantic proximity Read ↗

Primate Lentivirus Capsid Sensitivity to TRIM5 ProteinsSemantic proximity Read ↗

Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization.Semantic proximity Read ↗

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