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Article

Retroviral restriction factor TRIM5alpha is a trimer.

Journal of virology - 1 Nov 2005

Mische Claudia C, Javanbakht Hassan, Song Byeongwoon, Diaz-Griffero Felipe, Stremlau Matthew, Strack Bettina, Si Zhihai, Sodroski Joseph

Abstract excerpt

The retrovirus restriction factor TRIM5alpha targets the viral capsid soon after entry. Here we show that the TRIM5alpha protein oligomerizes into trimers. The TRIM5alpha coiled-coil and B30.2(SPRY) domains make important contributions to the formation and/or stability of the trimers. A functionally defective TRIM5alpha mutant with the RING and B-box 2 domains deleted can form heterotrimers with wild-type...

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Identifiers

PMID: 16254380
DOI: 10.1128/JVI.79.22.14446-14450.2005
PMCID: PMC1280198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Retroviral restriction factor TRIM5alpha is a trimer.PMID 16254380Read ↗

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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal DegradationSemantic proximity Read ↗

Functional Replacement of the RING, B-Box 2, and Coiled-Coil Domains of Tripartite Motif 5α (TRIM5α) by Heterologous TRIM DomainsSemantic proximity Read ↗

Unique features of TRIM5α among closely related human TRIM family membersSemantic proximity Read ↗

TRIM5α selectively binds a restriction-sensitive retroviral capsidSemantic proximity Read ↗

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