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Article

Primate Lentivirus Capsid Sensitivity to TRIM5 Proteins

17 Apr 2008

Abstract excerpt

Mammalian cells express several factors that inhibit lentiviral infection and that have been under strong selective pressure. One of these factors, TRIM5, targets the capsid protein of incoming retrovirus particles and inhibits subsequent steps of the replication cycle. By substituting human immunodeficiency virus type 1 capsid, we were able to show that a set of divergent primate lentivirus capsids was generally...

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PMID: 18417575
DOI: 10.1128/jvi.00410-08

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