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Article

CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5α.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2014

Zhao Gongpu, Zhang Peijun

Abstract excerpt

After virus fusion with a target cell, the viral core is released into the host cell cytoplasm and undergoes a controlled disassembly process, termed uncoating, before or as reverse transcription takes place. The cellular protein TRIM5α is a host cell restriction factor that blocks HIV-1 infection in rhesus macaque cells by targeting the viral capsid and inducing premature uncoating. The molecular mechanism of...

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Identifiers

PMID: 24158810
DOI: 10.1007/978-1-62703-670-2_2
PMCID: PMC4506781

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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