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Article

Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization.

Virology - 15 Sept 2010

Sastri Jaya, O'Connor Christopher, Danielson Cindy M, McRaven Michael, Perez Patricio, Diaz-Griffero Felipe, Campbell Edward M

Abstract excerpt

The intracellular restriction factor TRIM5alpha, inhibits infection by numerous retroviruses in a species-specific manner. The best characterized example of this restriction is the TRIM5alpha protein from rhesus macaques (rhTRIM5alpha), which potently inhibits HIV-1 infection. TRIM5alpha localizes to cytoplasmic assemblies of protein referred to as cytoplasmic bodies, though the role that these bodies play in...

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Identifiers

PMID: 20633914
DOI: 10.1016/j.virol.2010.06.015
PMCID: PMC2914212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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