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Article

RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoating.

Journal of virology - 1 Feb 2012

Roa Amanda, Hayashi Fumiaki, Yang Yang, Lienlaf Maritza, Zhou Jing, Shi Jiong, Watanabe Satoru, Kigawa Takanori, Yokoyama Shigeyuki, Aiken Christopher, Diaz-Griffero Felipe

Abstract excerpt

Rhesus TRIM5α (TRIM5α(rh)) is a cytosolic protein that potently restricts HIV-1 at an early postentry stage, prior to reverse transcription. The ability of TRIM5α(rh) to block HIV-1 infection has been correlated with a decrease of pelletable HIV-1 capsid during infection. To genetically dissect the ability of TRIM5α to block reverse transcription, we studied a set of TRIM5α(rh) RING domain mutants that potently...

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Identifiers

PMID: 22114335
DOI: 10.1128/JVI.05811-11
PMCID: PMC3264337

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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