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Article

Fates of Retroviral Core Components during Unrestricted and TRIM5-Restricted Infection

7 Mar 2013

Abstract excerpt

TRIM5 proteins can restrict retroviral infection soon after delivery of the viral core into the cytoplasm. However, the molecular mechanisms by which TRIM5α inhibits infection have been elusive, in part due to the difficulty of developing and executing biochemical assays that examine this stage of the retroviral life cycle. Prevailing models suggest that TRIM5α causes premature disassembly of retroviral capsids...

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PMID: 23505372
DOI: 10.1371/journal.ppat.1003214

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