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Article

TRIM5α selectively binds a restriction-sensitive retroviral capsid

20 Jun 2005

Abstract excerpt

TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid (CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the alpha-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5alpha binds retroviral CA from detergent-stripped virions in a...

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PMID: 15967037
DOI: 10.1186/1742-4690-2-40

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