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Article

The role of polymorphic HLA-DR beta chain residues in presentation of viral antigens to T cells.

The Journal of experimental medicine - 1 Jul 1990

Karr R W, Yu W, Watts R, Evans K S, Celis E

Abstract excerpt

The relative importance of 11 polymorphic positions in the HLA-DR7 beta 1 chain in T cell recognition of foreign antigens was investigated using transfectants expressing mutant DR7 beta 1 chains as APC for five rabies virus-specific T cell clones. The results indicate that multiple amino acids, located in both the beta-strands and alpha-helix of DR7 beta 1 in the model of a class II molecule, are involved in...

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Identifiers

PMID: 2358778
DOI: 10.1084/jem.172.1.273
PMCID: PMC2188176

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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