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Article

The role of polymorphic HLA-DR beta chain residues in presentation of viral antigens to T cells.

The Journal of experimental medicine - 1 Jul 1990

Karr R W, Yu W, Watts R, Evans K S, Celis E

Abstract excerpt

The relative importance of 11 polymorphic positions in the HLA-DR7 beta 1 chain in T cell recognition of foreign antigens was investigated using transfectants expressing mutant DR7 beta 1 chains as APC for five rabies virus-specific T cell clones. The results indicate that multiple amino acids, located in both the beta-strands and alpha-helix of DR7 beta 1 in the model of a class II molecule, are involved in...

Topics

Amino Acid Sequence
Antigen-Presenting Cells
Antigens, Viral
HLA-DR7 Antigen
Humans
Lymphocyte Activation
Molecular Sequence Data
Mutation
Peptides
Polymorphism, Genetic
Rabies virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

T-Lymphocytes

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 2358778
DOI: 10.1084/jem.172.1.273
PMCID: PMC2188176

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2358778-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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