Article
Critical contribution of beta chain residue 57 in peptide binding ability of both HLA-DR and -DQ molecules.
Proceedings of the National Academy of Sciences of the United States of America - 9 Jul 1996
Nepom B S, Nepom G T, Coleman M, Kwok W W
Abstract excerpt
Position 57 in the beta chain of HLA class II molecules maintains an Asp/non-Asp dimorphism that has been conserved through evolution and is implicated in susceptibility to some autoimmune diseases. The latter effect may be due to the influence of this residue on the ability of class II alleles t...
Topics
- Alleles
- Amino Acid Sequence
- Aspartic Acid
- B-Lymphocytes
- Binding Sites
- Biological Evolution
- Cell Line
- Conserved Sequence
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- HLA-DR Antigens
- Humans
- Molecular Sequence Data
- Oligopeptides
- Polymorphism, Genetic