Article
The specificity of alloreactive T cells is determined by MHC polymorphisms which contact the T cell receptor and which influence peptide binding.
International immunology - 1 Aug 1991
Lombardi G, Barber L, Sidhu S, Batchelor J R, Lechler R I
Abstract excerpt
The separate contributions to allorecognition of peptide-binding and T cell receptor-contacting residues of an allogeneic HLA-DR molecule were investigated by site-directed mutagenesis. Alloreactive T cell clones were generated from a combination of responder (DR1Dw1,DR4Dw14) and stimulator (DR1D...
Topics
- Animals
- Cross Reactions
- HLA-DR Antigens
- Mutation
- Peptide Fragments
- Polymorphism, Genetic
- Protein Conformation
- Rats
- Receptors, Antigen, T-Cell
- Structure-Activity Relationship
- T-Lymphocytes