Article
KCNN4 gene variant is associated with ileal Crohn's Disease in the Australian and New Zealand population.
The American journal of gastroenterology - 1 Oct 2010
Simms Lisa A, Doecke James D, Roberts Rebecca L, Fowler Elizabeth V, Zhao Zhen Zhen, McGuckin Michael A, Huang Ning, Hayward Nicholas K, Webb Penelope M, Whiteman David C, Cavanaugh Juleen A, McCallum Ruth, Florin Timothy H J, Barclay Murray L, Gearry Richard B, Merriman Tony R, Montgomery Grant W, Radford-Smith Graham L
Abstract excerpt
OBJECTIVES: Crohn's disease (CD; MIM 266600) is one of the most common forms of inflammatory bowel disease (IBD), and represents a significant burden to health care in developed countries. Our aim was to determine whether a gene in the IBD linkage region on chromosome 19q13, with a role in Paneth cell secretion and T-cell activation, conferred genetic susceptibility to the development of CD. METHODS: In total,...
Topics
- Adult
- Alleles
- Australia
- Chi-Square Distribution
- Colon
- Crohn Disease
- Female
- Gene Frequency
- Genetic Association Studies