Article
Interaction of Crohn's disease susceptibility genes in an Australian paediatric cohort.
PloS one - 8 Nov 2010
Wagner Josef, Sim Winnie H, Ellis Justine A, Ong Eng K, Catto-Smith Anthony G, Cameron Donald J S, Bishop Ruth F, Kirkwood Carl D
Abstract excerpt
Genetic susceptibility is an important contributor to the pathogenesis of Crohn's disease (CD). We investigated multiple CD susceptibility genes in an Australian paediatric onset CD cohort. Newly diagnosed paediatric onset CD patients (n = 72) and controls (n = 98) were genotyped for 34 single nucleotide polymorphisms (SNPs) in 18 genetic loci. Gene-gene interaction analysis, gene-disease phenotype analysis and...
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