Association analysis of 3p21 with Crohn's disease in a New Zealand population.

doi:10.1016/j.humimm.2010.03.003

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Article

Association analysis of 3p21 with Crohn's disease in a New Zealand population.

Human immunology - 1 Jun 2010

Morgan Angharad R, Han Dug-Yeo, Lam Wen-jiun, Fraser Alan G, Ferguson Lynnette R

Abstract excerpt

Recent genome-wide association studies have provided evidence for the involvement of 3p21 in the pathogenesis of Crohn's disease (CD). Here we attempted to validate the 3p21 region in a well characterized CD case-control New Zealand dataset of 329 CD patients and 521 controls by genotyping tagging single nucleotide polymorphisms (SNPs) across this region. Analysis revealed significant differences between patients...

Topics

Adult
Case-Control Studies
Chromosomes, Human, Pair 3
Crohn Disease
DNA Mutational Analysis
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Haplotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Linkage Disequilibrium

Male

Middle Aged

New Zealand

Nod2 Signaling Adaptor Protein

Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 20307617
DOI: 10.1016/j.humimm.2010.03.003

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