Associations between NOD2, IRGM and ORMDL3 polymorphisms and pediatric-onset inflammatory bowel disease in the Lithuanian population.

doi:10.1016/j.medici.2016.11.006

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Associations between NOD2, IRGM and ORMDL3 polymorphisms and pediatric-onset inflammatory bowel disease in the Lithuanian population.

Medicina (Kaunas, Lithuania) - 1 Jan 2016

Pranculienė Gitana, Steponaitienė Rūta, Skiecevičienė Jurgita, Kučinskienė Rūta, Kiudelis Gediminas, Adamonis Kęstutis, Labanauskas Liutauras, Kupčinskas Limas

Abstract excerpt

BACKGROUND AND OBJECTIVE: Recent GWAS and meta-analyses have revealed about 200 susceptibility genes/loci for inflammatory bowel diseases (IBD). However, only a small number of studies were performed in early-onset IBD. The aim of this study was to assess the association between NOD2, IL23R, ATG16L1, IRGM, IL10, NKX2-3 and ORMDL3 variants and early-onset IBD. MATERIALS AND METHODS: A total of 76 affected...

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Associations between NOD2, IRGM and ORMDL3 polymorphisms and pediatric-onset inflammatory bowel disease in the Lithuanian population.

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