Article
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study.
Lancet (London, England) - 9 Jan 2016
Cleynen Isabelle, Boucher Gabrielle, Jostins Luke, Schumm L Philip, Zeissig Sebastian, Ahmad Tariq, Andersen Vibeke, Andrews Jane M, Annese Vito, Brand Stephan, Brant Steven R, Cho Judy H, Daly Mark J, Dubinsky Marla, Duerr Richard H, Ferguson Lynnette R, Franke Andre, Gearry Richard B, Goyette Philippe, Hakonarson Hakon, Halfvarson Jonas, Hov Johannes R, Huang Hailang, Kennedy Nicholas A, Kupcinskas Limas, Lawrance Ian C, Lee James C, Satsangi Jack, Schreiber Stephan, Théâtre Emilie, van der Meulen-de Jong Andrea E, Weersma Rinse K, Wilson David C, Parkes Miles, Vermeire Severine, Rioux John D, Mansfield John, Silverberg Mark S, Radford-Smith Graham, McGovern Dermot P B, Barrett Jeffrey C, Lees Charlie W
Abstract excerpt
BACKGROUND: Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease and ulcerative colitis. We undertook the largest genotype association study, to date, in widely...
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