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Article

Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease.

Inflammatory bowel diseases - 1 Jul 2010

Latiano Anna, Palmieri Orazio, Corritore Giuseppe, Valvano Maria Rosa, Bossa Fabrizio, Cucchiara Salvatore, Castro Massimo, Riegler Gabriele, De Venuto Domenica, D'Incà Renata, Andriulli Angelo, Annese Vito

Abstract excerpt

BACKGROUND: To date, a number of high-profile studies have yielded over 50 inflammatory bowel disease (IBD) disease genes/loci. The polymorphisms rs9858542 (BSN) and rs3197999 (MST1), on 3p21 locus, have been found associated with susceptibility to IBD. We aimed to replicate these associations in adult and early-onset cohorts of IBD Italian patients, by analyzing also potential gene-gene interactions with...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Autophagy-Related Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Carrier Proteins

Child

Child, Preschool

Chromosomes, Human, Pair 3

Colitis, Ulcerative

Crohn Disease

Female

GTP-Binding Proteins

Genetic Association Studies

Genetic Predisposition to Disease

Genotype

Haplotypes

Humans

Source

Identifiers

PMID: 20024904
DOI: 10.1002/ibd.21176

Genes

BSN
MST1
IRGM
NOD2

Provenance

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