Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population.

doi:10.1002/ibd.20362

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Article

Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population.

Inflammatory bowel diseases - 1 May 2008

Hume Georgia E, Fowler Elizabeth V, Doecke James, Simms Lisa A, Huang Ning, Palmieri Orazio, Griffiths Lyn R, Florin Timothy H J, Annese Vito, Radford-Smith Graham L

Abstract excerpt

BACKGROUND: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic, debilitating disorder. These include the Toll-like receptors, specifically TLR4 and TLR5. A variant in the TLR4 gene (A299G) has demonstrated variable association with CD. We aimed to investigate the relationship...

Topics

Adolescent
Adult
Crohn Disease
DNA
Female
Gene Frequency
Haplotypes
Humans
Incidence
Male
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nod2 Signaling Adaptor Protein

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Prospective Studies

Queensland

Toll-Like Receptor 4

Source

Open in PubMed

Identifiers

PMID: 18213697
DOI: 10.1002/ibd.20362

Genes

TLR4
NOD2
TLR5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population.PMID 18213697Read ↗

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